---
title: "EP #211 Claude Opus 4.5, White House \"Genesis Mission\" & Amazon's $50B AI Push w/ Emad Mostaque, Salim Ismail, Dave Blundin & Alexander Wissner-Gross"
description: Claude Opus 4.5, the White House’s “Genesis Mission,” and Amazon’s $50B AI push—this week’s biggest AI power moves.
---

[Moonshots with Peter Diamandis ](https://www.diamandis.com/podcast)

# [EP #211 Claude Opus 4.5, White House "Genesis Mission" & Amazon's $50B AI Push w/ Emad Mostaque, Salim Ismail, Dave Blundin & Alexander Wissner-Gross](https://www.diamandis.com/podcast/claude-opus-4-5-amazon-50b-ai-push)

 Written by [Peter H. Diamandis](https://www.diamandis.com/podcast/author/peter-h-diamandis) | Nov 26, 2025 8:00:00 AM

If you want us to build a MOONSHOT Summit, email my team: [moonshots@diamandis.com](mailto:moonshots@diamandis.com) 

Get access to metatrends 10+ years before anyone else - [https://qr.diamandis.com/metatrends](https://qr.diamandis.com/metatrends)  

Emad Mostaque is the founder of Intelligent Internet ( [https://www.ii.inc](https://www.ii.inc) ) 

Read Emad’s Book: [https://thelasteconomy.com](https://thelasteconomy.com) 

Salim Ismail is the founder of OpenExO

Dave Blundin is the founder & GP of Link Ventures

Dr. Alexander Wissner-Gross is a computer scientist and founder of Reified

## RESOURCES

My companies:

Apply to Dave's and my new fund:[https://qr.diamandis.com/linkventureslanding](https://qr.diamandis.com/linkventureslanding)  

Go to Blitzy to book a free demo and start building today: [https://qr.diamandis.com/blitzy](https://qr.diamandis.com/blitzy)  

Grab dinner with MOONSHOT listeners: [https://moonshots.dnnr.io/](https://moonshots.dnnr.io/)

[View full post](https://www.diamandis.com/podcast/claude-opus-4-5-amazon-50b-ai-push)

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