Age Reversal for All by 2040?

Metatrend #3: Longevity Revolution & Human Enhancement

What it is

 Longevity is no longer just for the wealthy, it’s heading toward mass adoption. Just like cell phones went from $10,000 bricks to $100 smartphones, life-extension tech is racing down the same curve. Take genome sequencing: $100M and 9 months in 2001, now as low as $200 and 7 hours. That’s a 500,000-fold drop in cost and a 900-fold increase in speed. Covid mRNA vaccines proved we can scale gene therapies to billions of people for $1 to 2 per dose.

Aging is the one “disease” every human shares. That means what works in California will work in Calcutta. By 2040, longevity could be cheap, fast, and accessible to all. It will be the biggest business on the planet and the greatest gift we can offer to humanity.

Why it matters

Longevity tech is being demonetized and democratized fast. Here are a few proof points… 

3 Developments Democratizing Longevity

1. Epigenetic Reprogramming: What if you could reverse your biological age? It's likely that epigenetic reprogramming delivered by gene therapies will be the technology that most impacts our ability to live past 100 years old.

While gene therapies have historically been very expensive with price tags like $500,000, a company called Rejuvenate Bio was recently able to reliably reduce the cost to $100 per gene therapy. At the same time, leading epigenetic reprogramming companies like Altos Labs have raised billions of dollars to advance the field, while Life Biosciences and Retro Bio are preparing to enter clinical trials. 

NOTE: We’ll be visiting the Harvard lab of Dr. David Sinclair, one of the world’s leading scientists on reversing epigenetic aging, as part of my Longevity Platinum Trip this September. To learn more and request your private invitation, click here.

2. Demonetizing Diagnostics: Our bodies are really good at hiding disease. For example, 70% of all heart attacks have no precedent, and you don’t feel the symptoms of cancer until it has reached stage 3 or stage 4.

The only way to know is to look.

Today, longevity centers like Fountain Life, The Aria Health Institute, Biograph and others are able to offer various advanced diagnostic services. While still expensive and out of reach for most people, the good news is that ongoing breakthroughs in AI and sensors are rapidly demonetizing diagnostics.

3. XPRIZE Healthspan: The $101M XPRIZE Healthspan launched in November 2023 with the audacious goal of adding 20 healthy years to your life. Roughly 18 months later, we're seeing significant momentum as this seven-year global competition has attracted over 620 teams.

At its core, XPRIZE Healthspan challenges teams worldwide to develop therapeutic solutions that target three critical systems essential to healthy aging: muscular, immune, and cognitive function. The objective of this XPRIZE competition is to demonstrate and inspire longevity (healthspan-extending) technologies that offer equitable, demonetized, and democratized access.

Your Mission…

In his groundbreaking book Fantastic Voyage: Live Long Enough to Live Forever, my dear friend Ray Kurzweil outlines three "bridges" to achieve longevity: near-term life-extending solutions, advanced medical interventions, and nanotechnology. 

Your mission is to stay healthy long enough to intercept many of the bridge-two breakthroughs racing towards us.

Here are a few free and cheap ways to boost your health and longevity TODAY: 

• Change Your Mindset & Become More Optimistic: In a study of 69,744 women and 1,429 men, published in the prestigious journal Proceedings of the National Academy of Science, it was found that optimistic people live as much as 15% longer than pessimists. The study was conducted over the course of three decades, controlling for health conditions, behaviors like diet and exercise, and other demographic factors.
• Exercise More: This is the single most impactful thing you can do for your longevity. For those over 60, exercising just twice per week with weights can reduce all-cause mortality by 50% and lower cancer risk three-fold.
• Change Your Diet: The American diet is killing people. Minimizing sugar consumption is fundamental – the human body never evolved to consume as much sugar as we do today. For reference, in the year 1700, average sugar consumption was 4 pounds per person per year. Today, it’s exploded to over 75 pounds per year. Excessive sugar consumption can trigger inflammatory responses in cardiovascular and neurological systems. Consider eating a whole-plant diet and eliminating processed foods.
• Invest in Low-Cost Longevity Products (<$250): Here are three products I personally use: ProLon Fasting Mimicking Diet ($250), a 5-day diet program offering fasting benefits without extreme calorie restriction; a continuous glucose monitor (CGM) ($200) to track your blood glucose in real-time to optimize your metabolic health; and an InBody H20N Smart Weight Analyzer ($200) to monitor your body composition, muscle mass, and fat percentage.

How many of the above behaviors are you practicing?

Other Key Tech Developments This Week:

1

Parallel Bio raises $21M to cut drug discovery costs by $2B and 9 years using human tissue over animal testing

2

MIT creates self-teaching AI that generates its own training data to autonomously improve performance

3

AI brain implant restores natural speech and singing for ALS patient with near-zero delay

Until next time,

Peter